RESUMO
Histoplasmosis was diagnosed histopathologically in a female chinchilla. This animal had originated from a commercial chinchilla ranch in central Missouri. Seventeen of 130 animals in the colony had died within a month's period with a respiratory illness. This animal had a history of fur chewing, but this was not true of all the other animals that had died. Histoplasma capsulatum was cultured from timothy hay used for food.
Assuntos
Chinchila , Histoplasmose/veterinária , Ração Animal , Animais , Feminino , Contaminação de Alimentos , Microbiologia de Alimentos , Histoplasma/isolamento & purificação , Histoplasmose/microbiologia , Histoplasmose/patologia , Especificidade de Órgãos , Estados UnidosAssuntos
Antibacterianos/uso terapêutico , Carbamatos/uso terapêutico , Quinoxalinas/uso terapêutico , Salmonelose Animal/tratamento farmacológico , Doenças dos Suínos/tratamento farmacológico , Administração Oral , Animais , Temperatura Corporal , Peso Corporal , Colite/etiologia , Colite/veterinária , Diarreia/etiologia , Diarreia/veterinária , Feminino , Masculino , Salmonella/isolamento & purificação , Salmonelose Animal/etiologia , Salmonelose Animal/microbiologia , Salmonelose Animal/patologia , Suínos , Doenças dos Suínos/etiologia , Doenças dos Suínos/microbiologia , Doenças dos Suínos/patologiaAssuntos
Doenças do Cão , Gastroenteropatias/veterinária , Hipoproteinemia/veterinária , Animais , Proteínas Sanguíneas/análise , Doença Crônica , Diarreia/etiologia , Diarreia/veterinária , Cães , Edema/etiologia , Edema/veterinária , Fezes/enzimologia , Feminino , Gastroenteropatias/complicações , Gastroenteropatias/patologia , Hematócrito , Hidrotórax/etiologia , Hidrotórax/veterinária , Hipoproteinemia/etiologia , Absorção Intestinal , Intestino Delgado/patologia , Contagem de Leucócitos , Masculino , Enteropatias Perdedoras de Proteínas/veterinária , Tripsina/análise , Urina/análiseAssuntos
Gastroenterite Suína Transmissível/microbiologia , Vírus não Classificados/patogenicidade , Doenças dos Animais/imunologia , Doenças dos Animais/microbiologia , Animais , Anticorpos/análise , Portador Sadio/veterinária , Doenças do Gato/imunologia , Gatos , Bovinos , Embrião de Galinha , Cricetinae , Doenças do Cão/imunologia , Cães , Fezes/microbiologia , Cobaias , Cavalos , Humanos , Soros Imunes/análise , Mucosa Intestinal/microbiologia , Camundongos , Testes de Neutralização , Coelhos , Estações do Ano , Ovinos , Especificidade da Espécie , Suínos , Extratos de Tecidos/administração & dosagemRESUMO
Gross, subgross and histological lesions were studied in 103 pigs infected with transmissible gastroenteritis virus and killed at daily intervals for 14 days. Twenty-three pigs served as controls. Thirty-six pigs were given colchicine four hours prior to being killed in order to determine the mitotic activity in the gastrointestinal tract. The gross lesions consisted of dehydration, excessive milk curd in the stomach, focal hemorrhage in the submucosa of the diverticulum ventriculi of the stomach, fundic and pyloric congestion in severly dehydrated animals and thinning of the small intestinal wall. The major subgross lesion was a marked shortening of the villi in the lower duodenum, jejunum and ileum within 24 hours after exposure to the virus. Regrowth of the villi became evident on about the sixth day after infection. Histological examination of the small intestine revealed that the villus-height/crypt-depth ratio in the jejunum was reduced from 7:1 in normal pigs to less than 1:1 in infected pigs. Villous atrophy was less severe in the proximal duodenum and ileum. Cells covering the atrophic villi were flatened or cuboidal and did not have well defined brush borders. Inflammatory changes in the gastrointestinal tract were minimal at all stages of infection. Goblet cell numbers increased slightly in the recovery stage of the disease and small numbers of mononuclear cells accumulated in the lamina propria during regrowth of the villi. The number of metaphase nuclei in the small intestinal crypts of infected pigs was greater than in normal pigs.
